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Valium History Leo Sternbach

Diazepam was the second benzodiazepine to beinvented by Leo Sternbach around 1960.

Valium/Diazepam is five times more potent than its predecessor, chlordiazepoxide (Librium®), which it quickly overtook when first marketed in 1963. The benzodiazepines gained popularity amongmedical professionals as an improvement upon barbiturates, which have a comparatively narrow therapeutic index. At first, diazepam was considered something of a"wonder-drug": it was America's top-selling pharmaceutical from 1969 to 1982, with peak sales in 1978 of 2.3 billion pills ($US600 million in sales).

However, it is now known that benzodiazepines carry a risk of dependency. In the autumn of 1973, a report aired on the television show 60 Minutes attesting to the drug's addictiveness. This can occur in as little as four weeks. Following a controversial and often polemic discussion, benzodiazepine prescriptions declined by nearly half in the 1980's and 1990's.

Psychiatrists and neurologists have recently discovered new off-label uses for this 'old' drug, such as adjunctive treatment of extrapyramidal disorders or spastic paresis. This is most likely due to the inhibitory effects of the benzodiazepines.

Read the official biography of Leo Sternbach at Roches official webpage

 

 

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